Desaturation and Chain-elongation of Fatty Acids
نویسندگان
چکیده
منابع مشابه
Fatty acid desaturation and chain elongation in eukaryotes
Although the contribution of lipid molecules to the hydrophobic character of membranes was recognized late in the nineteenth century, the nutritional importance of specific lipid molecules was first revealed through the pioneering work of Burr and Burr in 1929. They fed rats a fat-free diet and observed that retarded growth, scaly skin, tail necrosis and eventual death were reversed by feeding ...
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BACKGROUND Hormone-sensitive lipase (HSL) is expressed predominantly in adipose tissue, where it plays an important role in catecholamine-stimulated hydrolysis of stored lipids, thus mobilizing fatty acids. HSL exhibits broad substrate specificity and besides acylglycerides it hydrolyzes cholesteryl esters, retinyl esters and lipoidal esters. Despite its role in fatty acid mobilization, HSL nul...
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Chain elongation and 2-hydroxylation pathways, which are specific for very long chain fatty acids ( >C&), have been found in the yeast, Candida utitis. The chain elongation system acts specifically on fatty acids of chain length C2,, to CZ4; there is no detectable elongation of Cl* and only trace . . . actrvrty with C&,. The product of the elongation enzyme or enzymes is C& when Co, C&, or C24 ...
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The activity of the enzyme system involved in desaturation of palmitic and stearic acid has been examined in lungs of rats fed fat-free diets supplemented either with 4% safflower oil (controls) or 4% tripalmitin (essential fatty acid (EFA) deficient) both in vivo and in vitro in lung slices. Desaturation, as measured by appearance of 14C-labeled monounsaturated fatty acid in pulmonary total li...
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ژورنال
عنوان ژورنال: Journal of Japan Oil Chemists' Society
سال: 1971
ISSN: 1884-2003
DOI: 10.5650/jos1956.20.670